Spontaneous Pneumorrachis: A Complication of Nitrous Oxide Inhalation and Cocaine Snorting-Juniper publishers
JUNIPER PUBLISHERS-OPEN ACCESS JOURNAL OF HEAD NECK & SPINE SURGERY
Abstract
Context: Pneumorrhachis (PR) is an uncommon
condition characterized by the presence of air within the spinal canal.
Usually it results following trauma or surgery involving spinal
instrumentation. Spontaneous pnemorrachis has also been described in
association with spontaneous pneumomediastinum or secondary to marijuana
smoking and cocaine snorting.
Findings: We report a case of spontaneous
pnemorrachis in a patient who was snorting cocaine along with nitrous
oxide inhalation for recreation.
Conclusion: It is helpful to elicit a history of illicit drug use, particularly regarding cocaine in a case of spontaneous pneumorrhachis.
Keywords: Pnemothorax; Drug abuse; Spine non trauma
Case Report
A 19 year male came to emergency department with
shortness of breath and pleuritic chest pain. He had a history of
inhalation of nitrous oxide and cocaine. He denied any trauma or recent
air travel. On clinical examination he was anxious and tachypneic. There
was extensive crepitus over the neck and anterior chest. CT scan of the
chest showed extensive subcutaneous emphysema with pneumo-mediastinum
and interstitial emphysema. Traces of pnemothoraces were seen in the
apices and air was seen in spinal canal at C7/T1 level (Figure 1a & 1b).
CT scan of the brain was reported to be normal. The neurological
examination was entirely normal. He was managed conservatively with high
flow oxygen inhalation. He improved clinically after 48 hours and was
subsequently discharged for outpatients follow up.
Spontaneous pnemorrachis is a rare entity, with one
study reporting an incidence of 9.5% in a group of paediatric patient
with newly diagnosed spontaneous pnemo-mediastinum [1].
Uses of Illicit stimulants such as cocaine, amphetamines, and their
derivatives have been associated with development of pneumo-mediastinum [2].
Crack cocaine is most commonly associated with respiratory
complications requiring hospital admission. Injections of
methamphetamines have also been associated with pneumo-mediastinum and
subcutaneous emphysema, along with pneumorrhachis [3]. Pneumorrhachis is classified as internal, intra-dural, external, and extradural [4].
Intradural PR is recognized by the presence of pneumocephalus without a
head trauma wherein the air originates from a dural tear from a
penetrating spinal injury. Traumatic external (intraspinal or
extradural) PR usually recovers uneventfully; Traumatic internal PR is
associated with major trauma and can be considered a severity marker [5].
Pneumorrhachis has been reported to result from the
rupture of high-pressured alveoli (Macklin phenomenon) secondary to an
acute increase in the transalveolar pressure gradient during a Valsalva
manoeuvre. The air then may enter cervical subcutaneous tissues,
mediastinum, pericardium, and epidural space, in the latter via the
neural foramina and along the vascular and nerve root sheaths [6].
Of all the reported cases of spontaneous PR, four were reported to have developed neurologic signs and symptoms [710]. All the cases recovered without any specific intervention.
CT scan is the imaging modality of choice for
diagnosis but differentiation between internal and external PR is
difficult. Spontaneous PR is usually self limiting and there are no
established guidelines for the management of spontaneous PR. It is
usually treated conservatively as the air is reabsorbed by the blood
stream with no consequence. A thorough evaluation of patients presenting
with clinical signs and symptoms of pneumo-mediastinum should include a
meticulous neurologic evaluation and CT imaging of the neck and chest
to assess for concurrent PR.

Conclusion
Pneumorrachis is a self-limiting condition and
resolves without any consequences. Prompt recognition of the underlying
cause is essential for management planning. It is helpful to elicit a
history of illicit drug use, particularly regarding amphetamines and
cocaine.
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