JUNIPER PUBLISHERS-OPEN ACCESS JOURNAL OF HEAD NECK & SPINE SURGERY
JUNIPER PUBLISHERS-OPEN ACCESS JOURNAL OF HEAD NECK & SPINE SURGERY Did Randomized Clinical Trials (RCT) and Continually are Contributing Evidence for Progress in Radiation Oncology Authored by Bogusław Maciejewski Since clinical trials have been advocated as evidence based guidelines for radiotherapy many RCTs were carried out. Can they be considered compared with empirical studies, as a milestone progress in radiation oncology. Large heterogenous tumor sites and stages were enrolled into the trials on hyperoxygen therapy, radiosensitizers and altered fractionations raise some uncertainties and criticism regarding therapeutic gain usually reported as median end-points. Local tumor control rates have been and still are related to the tumor TNM status, but almost never to initial tumor volume (number of initial cancer stem cells) whereas the effect of irradiation is cell killing, not tumor stage killing. Many RCTs became disappointing or at least therapeut