Endolymphatic Sac Tumor of The Temporal Bone
Journal of Head Neck & Spine Surgery Juniper Publishers Author By: Behzad Saberi Opinion Endolymphatic sac tumor of the temporal bone is a locally aggressive tumor which involves the sac and the endolymphatic duct. From the histological point of view, endolymphatic sac tumor can be described as a destructive papillary cystic adenomatous tumor. It can be sporadic or related to the von Hippel-Lindau disease. Chromosome 3p25 tumor suppressor gene’s loss of function can cause von Hippel-Lindau which the patients with von Hippel-Lindau disease may have bilateral endolymphatic sac tumors. So, it is advisable to screen the patients with von Hippel-Lindau disease for the presence of bilateral endolymphatic sac tumors. Patients with endolymphatic sac tumors can be presented with various symptoms like aural fullness, sensorineural hearing loss, vertigo and tinnitus which seemingly are due to endolymph’s normal flow and resorption patterns obstruction which may cause endolymphatic hydrops.